Opportunités de carrière : Postdoc Position In Tumour Tissue Engineering (20998)
Identifiant de demande de recrutement 20998 - Publié - Type de poste (1) - Domaines et disciplines (1) - Taux d’activité (1) - Faculté / Service (1) - Catégorie personnel (1)
Introduction
UNIL is a leading international teaching and research institution, with over 5,000 employees and 17,000 students split between its Dorigny campus, CHUV and Epalinges. As an employer, UNIL encourages excellence, individual recognition and responsibility.
Are you interested in stem cells and cancer, and want to work in a diverse and multicultural lab at the heart of the Swiss Alps in the scenic city of Lausanne?
Presentation
A Postdoc position in tissue engineering is available in the Habib lab (www.habiblab.org) at the department of Biomedical Sciences at the University of Lausanne.
The Habib lab has engineered a novel human bone tissue that maintains bone-stem cells and a cascade of osteogenic differentiation. The tissue can be used not only for drug screening and osteogenesis modelling but can be incorporated into novel bandages that can promote bone repair in vivo. These technologies resulted in a patent, over 107 news articles and a televised coverage in CBS-News.
Despite surgery and chemotherapy, long-term survival rates for patients of the bone cancer osteosarcoma have not improved for three decades. Osteosarcoma remains the second leading cause of cancer-related deaths in paediatric patients.
Osteosarcoma stem cells (OSCS) derive the tumour growth. This project will utilise OSCs and healthy bone stem cells to engineer 3D osteosarcomas. The Postdoc will increase the complexity of the tissue by adding immune and vasculature cells that are found in bone and tumour environments in vivo. They will initially investigate the epigenetic and metabolic profiles of the engineered tissue and the impact of the scaffold on tumour development. They will apply RNAseq, gene editing and CRISPR approaches to investigate specific pathways that impact the tumour tissue formation. The engineered tumour tissue will be subjected to a high-throughput drug screen to identify molecules that can target OSCs and their progeny in vitro and in osteosarcoma animal models.
This project will build on our recent progress in this area (Okuchi et al Nature Materials 2021). You should hold a PhD degree in a biological/bioengineering sciences or related disciplines, be highly motivated and have an interest in tumour biology, immunology, and bioengineering.
Job information
Expected start date in position : 01.06.2024 (or to be agreed)
Contract length : 1 year, renewable 1 year.
Activity rate : 100%
Workplace : University of Lausanne, Department of Biomedical sciences (DBS, https://www.unil.ch/dsb/fr/home.html)
Your responsibilities
· Develop and undertake research of high quality consistent with making an active contribution in line with the lab and department research strategies
· Purification of signalling proteins (e.g., Wnt)
· Biomaterial synthesis
· Assist in data analysis and bioinformatics
· Assist in gene cloning and genome editing
· Working with mice as an animal model for research
· Contribute to the general day-to-day running of the tissue culture and research laboratory, including preparation of communal media and solutions, maintenance of equipment and maintaining stocks of consumables
· Apply for fellowships
· Carry out individual research project with minimal supervision to an agreed timeline and within a specific budget
· Assist the group leader and department manager in ensuring compliance with Health and Safety regulations within the group
· Attend and, as appropriate, present research findings at internal meetings and external conferences
· Facilitate collaboration and networking which engages and supports the activities of the Habib lab and the Centre as a whole
· Contribute to publications arising from the research projects
· From time to time, the post-holder may be required to perform other duties appropriate to the grade of the post within the department and division.
· To use a broad range of technical or practical skills and a well-developed working knowledge of technical or scientific practices and procedures acquired through on-the-job experience and/or vocational training
· To provide colleagues with advice and guidance as required
· To be responsive to changing priorities and an evolving environment/context, maximising the efficiency of the technical support being provided and resolving problems as they arise
· To forge relationships with colleagues in the Department, Faculty and University, in order to deliver the required support as well as to contribute to process development and the adoption of best practice
· To foster a stimulating, innovative and inclusive cultural environment across the faculty enabling students and staff to thrive and develop, ensuring that processes and policies are visible, accessible and transparent
· To provide advice and guidance and, where appropriate, training on university policies, processes and where required, source information and support for colleagues to facilitate their work
· To actively engage in Continuing Professional Development and training initiatives, in line with the Post-doc Commitment.
· To take part in public out-reach when needed.
Your qualifications
You must hold PhD in Biological/Bioengineering sciences or relevant disciplines, or PhD is near completion. You should have at least one first author publication.
To complete our team, we are looking for someone with the following skills:
Essential criteria
1. Experience in cancer and immunology research.
2. Experience in working in Tissue Culture.
3. Experience in gene cloning/editing.
4. Experience in microscopy.
5. Experience in bioengineering
Desirable criteria
1. Ability to handle animals for experimental work.
2. Experience in bone and micro-CT tomography.
2. Experience in biomaterials and tissue engineering.
4. Knowledge in epigenetics.
5. Knowledge in cell metabolism.
6. Experience in tissue processing.
What the position offers you
Lausanne enjoys an international scientific environment. The lab is adjacent to the CHUV hospital and has access to the state-of-art multi-institute bioengineering and imaging platforms at Agora. We offer a competitive salary, international collaboration, an inclusive working place in a multicultural, diverse and dynamic academic environment. Opportunities for professional training, attending national and international meetings and access to UNIL sports and wellbeing facilities. The group leader will support the candidate to apply for fellowships.
Contact for further information
Your application
Deadline : 10.05.2024
You must hold a PhD in biology/bioengineering or relevant disciplines. Please submit your CV (maximum 2 sides of A4), publication list and a covering letter. In your covering letter (maximum one side of A4), please summarize your previous research experience(s) and explain how you meet the criteria above.
Please, send your full application in Word or PDF.
Only applications through this website will be taken into account.
We thank you for your understanding.
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