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Pharmacokinetics of Drug-in-Polymer Matrix-Based Nanoparticulate Drug Delivery System

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Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems

Abstract

The application of nanotechnology in drug delivery is gaining much attention from researchers due to their plethora of benefits especially in the improvement of pharmacokinetics as compared to conventionally available dosage forms. In this line, numerous advanced approaches have been adopted that demonstrated excellent applicability in the drug delivery systems. Despite this, they are lacking the foremost limitations related to absorption, distribution, metabolism, and excretion of the drug that affect the therapeutics of the active. Noteworthily, polymeric materials offer several advantages such as biocompatibility, biodegradability, and other tunable properties, which are playing a crucial function in advanced drug delivery systems. In recent times, a drug-in-polymer matrix (DPM)-based nanoparticulate drug delivery system (NPDDS) is majorly employed for designing different types of advanced formulations. Herein, polymeric materials are widely utilized as drug carriers that assist to accomplish the intended pharmacokinetic parameter with minimum adverse effects. Notably, published pieces of literature divulged that the DPM can effortlessly modulate the absorption, distribution, metabolism, and excretion of a drug as compared to other reported advanced approaches in drug delivery. Thus, in this chapter, we have provided the essentials for the pharmacokinetics of DPM-based NPDDS. In addition, we have discussed the different types of dosage forms based on the DPM system and their modified pharmacokinetics. Finally, we have shed light on current challenges and future prospects of DPM-based NPDDS. In conclusion, the DPM-based NPDDS can modify pharmacokinetic parameters, namely, absorption, distribution, metabolism, and excretion of the administered active. In the future, this chapter will furnish a new way of designing DPM-based advanced dosage forms with acceptable pharmacokinetics.

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Acknowledgments

The authors are thankful to H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, for providing the necessary facilities.

Conflict of Interest

The authors declare no conflict of interest.

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Author notes

  1. Prashant Patil contributed equally with all other contributors.

Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Karvand Naka, Shirpur, Maharashtra, India

    Sopan Nangare, Prashant Patil, Zamir Khan, Rahul Tade & Pravin Patil

  2. Department of Microbiology, R. C. Patel Arts, Science, and Commerce College, Karvand Naka, Shirpur, Maharashtra, India

    Ashwini Patil

  3. Department of Pharmaceutics, Dr. Rajendra Gode College of Pharmacy, Malkapur, Maharashtra, India

    Prashant Deshmukh

  4. Department of Pharmaceutics, Smt. Kashibai Navale College of Pharmacy, Kondhwa, Maharashtra, India

    Trupti Powar

  5. Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India

    Jidnyasa Pantwalawalkar

  6. Nootan Pharmacy College, Faculty of Pharmacy, Sankalchand Patel University, Visnagar, Gujarat, India

    Jayvadan K. Patel

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  1. Sopan Nangare
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Editors and Affiliations

  1. Nootan Pharmacy College, Faculty of Pharmacy, Sankalchand Patel University, Visnagar, Gujarat, India

    Jayvadan K. Patel

  2. College of Pharmacy, University of South Florida Health, Tampa, FL, USA

    Yashwant V. Pathak

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Nangare, S. et al. (2022). Pharmacokinetics of Drug-in-Polymer Matrix-Based Nanoparticulate Drug Delivery System. In: Patel, J.K., Pathak, Y.V. (eds) Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems . Springer, Cham. https://doi.org/10.1007/978-3-030-83395-4_9

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