Abstract
Drug delivery systems based on polymeric materials have recently improved targeted delivery. Here we review polymeric nano-assemblies, their targeting aspects and the development of nanoplatforms for curing breast cancer. We present polymeric materials for cargo delivery of various therapeutic and diagnostic agents. We also discuss the use of polymeric nanoparticles for clinical practice.
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References
Agarwal S, Dominic A, Wasnik S (2019) An overview of polymeric nanoparticles as potential cancer therapeutics. In: Polymeric nanoparticles as a promising tool for anti-cancer therapeutics. Elsevier, pp 21–34. https://doi.org/10.1016/B978-0-12-816963-6.00002-9
Ahlawat J, Henriquez G, Narayan M (2018) Enhancing the delivery of chemotherapeutics: role of biodegradable polymeric nanoparticles. Molecules 23:2157. https://doi.org/10.3390/molecules23092157
Alhasan AH, Fardous RS, Alsudir SA, Majrashi MA, Alghamdi WM, Alsharaeh EH, Almalik AM (2019) Polymeric reactor for the synthesis of superparamagnetic-thermal treatment of Breast cancer. Mol Pharm 16:3577–3587. https://doi.org/10.1021/acs.molpharmaceut.9b00433
Andrén OC, Zhang Y, Lundberg P, Hawker CJ, Nyström AM, Malkoch M (2017) Therapeutic nanocarriers via cholesterol directed self-assembly of well-defined linear-dendritic polymeric amphiphiles. Chem Mater 29:3891–3898. https://doi.org/10.1021/acs.chemmater.6b05095
Anselmo AC, Mitragotri S (2015) A review of clinical translation of inorganic nanoparticles. AAPS J 17:1041–1054. https://doi.org/10.1208/s12248-015-9780-2
Asadi H, Rostamizadeh K, Esmaeilzadeh A, Khodaei M, Fathi M (2018) Novel lipid-polymer hybrid nanoparticles for si RNA delivery and IGF-1R gene silencing in Breast cancer cells. J Drug Deliv Sci Technol 48:96–105. https://doi.org/10.1016/j.jddst.2018.08.025
Ashfaq UA, Riaz M, Yasmeen E, Yousaf MZ (2017) Recent advances in nanoparticle-based targeted drug-delivery systems against cancer and role of tumor microenvironment. Crit Rev Ther Drug Carrier Syst:34. https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2017017845
Avdeef A, Fuguet E, Llinàs A, Ràfols C, Bosch E, Völgyi G, Verbić T, Boldyreva E, Takács-Novák K (2016) Equilibrium solubility measurement of ionizable drugs–consensus recommendations for improving data quality. ADMET and DMPK 4:117–178. https://doi.org/10.1007/s12094-020-02507-3
Barzaman K, Karami J, Zarei Z, Hosseinzadeh A, Kazemi MH, Moradi-Kalbolandi S, Safari E, Farahmand L (2020) Breast cancer: biology, biomarkers, and treatments. Int Immunopharmacol 84:106535. https://doi.org/10.1016/j.intimp.2020.106535
Behdarvand N, Torbati MB, Shaabanzadeh M (2020) Tamoxifen-loaded PLA/DPPE-PEG lipid-polymeric nanocapsules for inhibiting the growth of estrogen-positive human Breast cancer cells through cell cycle arrest. J Nanopart Res 22:1–15. https://doi.org/10.1007/s11051-020-04990-9
Behera A, Padhi S (2020) Passive and active targeting strategies for the delivery of the camptothecin anticancer drug: a review. Environ Chem Lett 18:1557–1567. https://doi.org/10.1007/s10311-020-01022-9
Bennet D, Kim S (2014) Polymer nanoparticles for smart drug delivery. Appl Nanotechnol Drug Deliv:257–310. https://doi.org/10.5772/58422
Bhatia S (2016) Nanoparticles types, classification, characterization, fabrication methods and drug delivery applications. In: Natural polymer drug delivery systems. Springer, pp 33–93. https://doi.org/10.1007/978-3-319-41129-3_2
Bobde Y, Biswas S, Ghosh B (2020) PEGylated N-(2 hydroxypropyl) methacrylamide-doxorubicin conjugate as pH-responsive polymeric nanoparticles for cancer therapy. React Funct Polym 151:104561. https://doi.org/10.1016/j.reactfunctpolym.2020.104561Get
Calzoni E, Cesaretti A, Polchi A, Di Michele A, Tancini B, Emiliani C (2019) Biocompatible polymer nanoparticles for drug delivery applications in cancer and neurodegenerative disorder therapies. J funct biomater 10:4. https://doi.org/10.3390/jfb10010004
Carroll RT, Bhatia D, Geldenhuys W, Bhatia R, Miladore N, Bishayee A, Sutariya V (2010) Brain-targeted delivery of Tempol-loaded nanoparticles for neurological disorders. J Drug Target 18:665–674. https://doi.org/10.3109/10611861003639796
Chapman S, Dobrovolskaia M, Farahani K, Goodwin A, Joshi A, Lee H, Meade T, Pomper M, Ptak K, Rao J (2013) Nanoparticles for cancer imaging: the good, the bad, and the promise. Nano Today 8:454–460. https://doi.org/10.1016/j.nantod.2013.06.001
Cheow WS, Kiew TY, Yang Y, Hadinoto K (2014) Amorphization strategy affects the stability and supersaturation profile of amorphous drug nanoparticles. Mol Pharm 11:1611–1620. https://doi.org/10.1021/mp400788p
Chida T, Miura Y, Cabral H, Nomoto T, Kataoka K, Nishiyama N (2018) Epirubicin-loaded polymeric micelles effectively treat axillary lymph nodes metastasis of Breast cancer through selective accumulation and pH-triggered drug release. J Control Release 292:130–140. https://doi.org/10.1016/j.jconrel.2018.10.035
Chiu Y-L, Rana TM (2002) RNAi in human cells: basic structural and functional features of small interfering RNA. Mol Cell 10:549–561. https://doi.org/10.1016/S1097-2765(02)00652-4
Crucho CI, Barros MT (2017) Polymeric nanoparticles: a study on the preparation variables and characterization methods. Mater Sci Eng C 80:771–784. https://doi.org/10.1016/j.msec.2017.06.004
Dai X, Cheng H, Bai Z, Li J (2017) Breast cancer cell line classification and its relevance with breast tumor subtyping. J Cancer 8:3131. https://doi.org/10.7150/jca.18457
DeSantis CE, Ma J, Gaudet MM, Newman LA, Miller KD, Goding Sauer A, Jemal A, Siegel RL (2019) Breast cancer statistics, 2019. CA Cancer J Clin 69:438–451. https://doi.org/10.3322/caac.21583
Dhillon A, Kumar D (2018) Recent advances and perspectives in polymer-based nanomaterials for Cr (VI) removal. In: New polymer nanocomposites for environmental remediation. Elsevier, pp 29–46. https://doi.org/10.1016/B978-0-12-811033-1.00002-0
Di Sia P (2014) Present and future of nanotechnologies: peculiarities, phenomenology, theoretical modelling, perspectives. Rev Theor Sci 2:146–180. https://doi.org/10.1166/rits.2014.1019
Ding S, Lu L, Fan Y, Zhang F (2020) Recent progress in NIR-II emitting lanthanide-based nanoparticles and their biological applications. J Rare Earths. https://doi.org/10.1016/j.jre.2020.01.021
Empedocles S, Watson A, Jin J. (2015) Spatial positioning of spectrally labeled beads: Google Patents
Feng Y, Cheng Y, Chang Y, Jian H, Zheng R, Wu X, Xu K, Wang L, Ma X, Li X (2019) Time-staggered delivery of erlotinib and doxorubicin by gold nanocages with two smart polymers for reprogrammable release and synergistic with photothermal therapy. Biomaterials 217:119327. https://doi.org/10.1016/j.biomaterials.2019.119327
Gener P, Montero S, Xandri-Monje H, Díaz-Riascos ZV, Rafael D, Andrade F, Martínez-Trucharte F, González P, Seras-Franzoso J, Manzano A (2020) Zileuton™ loaded in polymer micelles effectively reduce Breast cancer circulating tumor cells and intratumoral cancer stem cells. Nanomedicine:24:102106. https://doi.org/10.1016/j.nano.2019.102106
Guo Z, Sui J, Ma M, Hu J, Sun Y, Yang L, Fan Y, Zhang X (2020) pH-Responsive charge switchable PEGylated ε-poly-l-lysine polymeric nanoparticles-assisted combination therapy for improving Breast cancer treatment. J Control Release 326:350–364. https://doi.org/10.1016/j.jconrel.2020.07.030
Gupta P, Zhang Y-K, Zhang X-Y, Wang Y-J, Lu KW, Hall T, Peng R, Yang D-H, Xie N, Chen Z-S (2018) Voruciclib, a potent CDK4/6 inhibitor, antagonizes ABreast cancerB1 and ABreast cancerG2-mediated multi-drug resistance in cancer cells. Cell Physiol Biochem 45:1515–1528. https://doi.org/10.1159/000487578
Han J, Zhao D, Li D, Wang X, Jin Z, Zhao K (2018) Polymer-based nanomaterials and applications for vaccines and drugs. Polymers 10:31. https://doi.org/10.3390/polym10010031
Harwansh RK, Deshmukh R (2020) Breast cancer: an insight into its inflammatory, molecular, pathological and targeted facets with update on investigational drugs. Crit Rev Oncol Hematol 154:103070. https://doi.org/10.1016/j.critrevonc.2020.103070
Hofmann AF, Mysels KJ (1992) Bile acid solubility and precipitation in vitro and in vivo: the role of conjugation, pH, and Ca2+ ions. J Lipid Res 33:617–626. https://doi.org/10.1016/S0022-2275(20)41426-9
Holt AP. (2016) The effect of attractive polymer-nanoparticle interactions on the local segmental dynamics of polymer nanocomposites
Hossain S, Hoque M (2018) Polymer nanocomposite materials in energy storage: properties and applications. In: Polymer-based nanocomposites for energy and environmental applications. Elsevier, pp 239–282. https://doi.org/10.1016/B978-0-08-102262-7.00009-X
Hu X, Tang Y, Hu Y, Lu F, Lu X, Wang Y, Li J, Li Y, Ji Y, Wang W (2019) Gadolinium-chelated conjugated polymer-based nanotheranostics for photoacoustic/magnetic resonance/NIR-II fluorescence imaging-guided cancer photothermal therapy. Theranostics 9:4168. https://doi.org/10.7150/thno.34390
Indoria S, Singh V, Hsieh MF (2020) Recent advances in theranostic polymeric nanoparticles for cancer treatment. Rev Int J Pharm:119314. https://doi.org/10.1016/j.ijpharm.2020.119314
Jadon RS, Sharma M (2019) Docetaxel-loaded lipid-polymer hybrid nanoparticles for Breast cancer therapeutics. J Drug Deliv Sci Technol 51:475–484. https://doi.org/10.1016/j.jddst.2019.03.039
Jagtap JM, Sharma G, Parchur AK (2020) Functional nanostructures for drug resistance Breast cancer theranostics. In: Nanomedicines for Breast cancer Theranostics. Elsevier, pp 131–152. https://doi.org/10.1016/B978-0-12-820016-2.00007-0
Jain NK, Dimri S, Prasad R, Ravichandran G, Naidu V, De A, Srivastava R (2020) Characteristics of molecularly engineered anticancer drug conjugated organic nanomicelles for site-selective cancer cell rupture and growth inhibition of tumor spheroids. ACS Appl Bio Mater 3:7067–7079. https://doi.org/10.1021/acsabm.0c00913
Jaymand M (2019) Chemically modified natural polymer-based theranostic nanomedicines: are they the golden gate toward a de novo clinical approach against cancer? ACS Biomater Sci Eng 6:134–166. https://doi.org/10.1021/acsbiomaterials.9b00802
Kadam RN, Shendge RS, Pande VV (2015) A review of nanotechnology with an emphasis on Nanoplex. Braz J Pharm Sci 51:255–263. https://doi.org/10.1590/S1984-82502015000200002
Kandasamy G, Sudame A, Maity D, Soni S, Sushmita K, Veerapu NS, Bose S, Tomy C (2019) Multifunctional magnetic-polymeric nanoparticles based ferrofluids for multi-modal in vitro cancer treatment using thermotherapy and chemotherapy. J Mol Liq 293:111549. https://doi.org/10.1016/j.molliq.2019.111549
Khuroo T, Verma D, Talegaonkar S, Padhi S, Panda A, Iqbal Z (2014) Topotecan–tamoxifen duple PLGA polymeric nanoparticles: investigation of in vitro, in vivo and cellular uptake potential. Int J Pharm 473:384–394. https://doi.org/10.1016/j.ijpharm.2014.07.022
Kumar P, Gajbhiye KR, Paknikar KM, Gajbhiye V (2019b) Current Status and Future Challenges of Various Polymers as Cancer Therapeutics. In: Polymeric Nanoparticles as a Promising Tool for Anti-cancer Therapeutics. Elsevier, pp 1–20. https://doi.org/10.1016/B978-0-12-816963-6.00001-7
Kumar P, Van Treuren T, Ranjan AP, Chaudhary P, Vishwanatha JK (2019a) In vivo imaging and biodistribution of near infrared dye loaded brain-metastatic-breast-cancer-cell-membrane coated polymeric nanoparticles. Nanotechnology 30:265101. https://doi.org/10.1088/1361-6528/ab0f46
Lan Y, Liang Q, Sun Y, Cao A, Liu L, Yu S, Zhou L, Liu J, Zhu R, Liu Y (2020) Codelivered chemotherapeutic doxorubicin via a dual-functional immunostimulatory polymeric prodrug for breast cancer immunochemotherapy. ACS Appl Mater Interfaces 12:31904–31921. https://doi.org/10.1021/acsami.0c06120
Li D, Zhang G, Xu W, Wang J, Wang Y, Qiu L, Ding J, Yang X (2017) Investigating the effect of chemical structure of semiconducting polymer nanoparticle on photothermal therapy and photoacoustic imaging. Theranostics 7:4029. https://doi.org/10.7150/thno.19538
Liu J, Li J, Rosol TJ, Pan X, Voorhees JL (2007) Biodegradable nanoparticles for targeted ultrasound imaging of Breast cancer cells in vitro. Phys Med Biol 52:4739. https://doi.org/10.1088/0031-9155/52/16/002
Luk BT, Fang RH, Zhang L (2012) Lipid-and polymer-based nanostructures for cancer theranostics. Theranostics 2:1117. https://doi.org/10.7150/thno.4381
Malik P, Mukherjee TK (2018) Recent advances in gold and silver nanoparticle based therapies for lung and Breast cancers. Int J Pharm 553:483–509. https://doi.org/10.1016/j.ijpharm.2018.10.048
Martínez-Jothar L, Beztsinna N, van Nostrum CF, Hennink WE, Oliveira S (2019) Selective cytotoxicity to HER2 positive Breast cancer cells by saporin-loaded nanobody-targeted polymeric nanoparticles in combination with photochemical internalization. Mol Pharm 16:1633–1647. https://doi.org/10.1021/acs.molpharmaceut.8b01318
Mehnath S, Arjama M, Rajan M, Jeyaraj M (2018) Development of cholate conjugated hybrid polymeric micelles for FXR receptor mediated effective site-specific delivery of paclitaxel. New J Chem 42:17021–17032. https://doi.org/10.1039/C8NJ03251C
Mi P (2020) Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics. Theranostics 10:4557. https://doi.org/10.7150/thno.38069
Mughees M, Wajid S, Samim M (2020) Cytotoxic potential of Artemisia absinthium extract loaded polymeric nanoparticles against Breast cancer cells: insight into the protein targets. Int J Pharm 586:119583. https://doi.org/10.1016/j.ijpharm.2020.119583
Ngamcherdtrakul W, Castro DJ, Gu S, Morry J, Reda M, Gray JW, Yantasee W (2016) Current development of targeted oligonucleotide-based cancer therapies: perspective on HER2-positive Breast cancer treatment. Cancer Treat Rev 45:19–29. https://doi.org/10.1016/j.ijpharm.2020.119583
Nguyen KT, Le DV, Do DH, Le QH (2016) Development of chitosan graft pluronic® F127 copolymer nanoparticles containing DNA aptamer for paclitaxel delivery to treat Breast cancer cells. Adv Nat Sci Nanosci Nanotechnol 7:025018. https://doi.org/10.1088/2043-6262/7/2/025018
Nicolas S, Bolzinger M-A, Jordheim LP, Chevalier Y, Fessi H, Almouazen E (2018) Polymeric nanocapsules as drug carriers for sustained anticancer activity of calcitriol in Breast cancer cells. Int J Pharm 550:170–179. https://doi.org/10.1016/j.ijpharm.2018.08.022
Nosrati H, Adinehvand R, Manjili HK, Rostamizadeh K, Danafar H (2019) Synthesis, characterization, and kinetic release study of methotrexate loaded mPEG–PCL polymersomes for inhibition of MCF-7 Breast cancer cell line. Pharm Dev Technol 24:89–98. https://doi.org/10.1080/10837450.2018.1425433
Padhi S, Behere A (2020) Nanotechnology based targeting strategies for the delivery of Camptothecin. In: Ankit S, Panda Amulya K, Eric L (eds) Pharmaceutical technology for natural products delivery, impact of nanotechnology. Springer, Cham, pp 243–272
Padhi S, Kapoor R, Verma D, Panda A, Iqbal Z (2018) Formulation and optimization of topotecan nanoparticles: in vitro characterization, cytotoxicity, cellular uptake and pharmacokinetic outcomes. J Photochem Photobiol B Biol 183:222–232. https://doi.org/10.1016/j.jphotobiol.2018.04.022
Padhi S, Mirza M, Verma D, Khuroo T, Panda A, Talegaonkar S et al (2015) Revisiting the nanoformulation design approach for effective delivery of topotecan in its stable form: an appraisal of its in vitro Behavior and tumor amelioration potential. Drug Del 23:2827–2837. https://doi.org/10.3109/10717544.2015.1105323
Padhi S, Nayak A, Behera A (2020) Type II diabetes mellitus: a review on recent drug based therapeutics. Biomed Pharmacother 131:110708. https://doi.org/10.1016/j.biopha.2020.110708
Panda J, Satapathy BS, Majumder S, Sarkar R, Mukherjee B, Tudu B (2019) Engineered polymeric iron oxide nanoparticles as potential drug carrier for targeted delivery of docetaxel to Breast cancer cells. J Magn Magn Mater 485:165–173. https://doi.org/10.1016/j.jmmm.2019.04.058
Patel P, Hanini A, Shah A, Patel D, Patel S, Bhatt P, Pathak YV (2019) Surface modification of nanoparticles for targeted drug delivery. In: Surface Modification of nanoparticles for targeted drug delivery. Springer, pp 19–31. https://doi.org/10.1007/978-3-030-06115-9_2
Phipps AI, Chlebowski RT, Prentice R, McTiernan A, Stefanick ML, Wactawski-Wende J, Kuller LH, Adams-Campbell LL, Lane D, Vitolins M (2011) Body size, physical activity, and risk of triple-negative and estrogen receptor–positive Breast cancer. Cancer Epidemiol Prev Biomarkers. https://doi.org/10.1158/1055-9965.EPI-10-0974
Ray P, Viles KD, Soule EE, Woodruff RS (2013) Application of aptamers for targeted therapeutics. Arch Immunol Ther Exp 61:255–271. https://doi.org/10.1007/s00005-013-0227-0
Ray S, Li Z, Hsu C-H, Hwang L-P, Lin Y-C, Chou P-T, Lin Y-Y (2018) Dendrimer-and copolymer-based nanoparticles for magnetic resonance cancer theranostics. Theranostics 8:6322. https://doi.org/10.7150/thno.27828
Rosa R, Monteleone F, Zambrano N, Bianco R (2014) In vitro and in vivo models for analysis of resistance to anticancer molecular therapies. Curr Med Chem 21:1595–1606
Scrivano L, Parisi OI, Iacopetta D, Ruffo M, Ceramella J, Sinicropi MS, Puoci F (2019) Molecularly imprinted hydrogels for sustained release of sunitinib in Breast cancer therapy. Polym Adv Technol 30:743–748. https://doi.org/10.1002/pat.4512
Soares DCF, Domingues SC, Viana DB, Tebaldi ML (2020) Polymer-hybrid nanoparticles: current advances in biomedical applications. Biomed Pharmacother 131:110695. https://doi.org/10.1016/j.biopha.2020.110695
Sukhanova A, Bozrova S, Sokolov P, Berestovoy M, Karaulov A, Nabiev I (2018) Dependence of nanoparticle toxicity on their physical and chemical properties. Nanoscale Res Lett 13:44. https://doi.org/10.1186/s11671-018-2457-x
Tade RS, Patil PO (2020) Theranostic prospects of Graphene quantum dots in breast cancer. ACS Biomater Sci Eng. https://doi.org/10.1021/acsbiomaterials.0c01045
Tavassoli F (2003) Tumours of the breast and female genital organs. Pathol Genet Tumors Digest Syst:10–80
Thorat ND, Bauer J (2020) Nanomedicine: next generation modality of Breast cancer therapeutics. In: Nanomedicines for breast cancer theranostics. Elsevier, pp 3–16. https://doi.org/10.1016/B978-0-12-820016-2.00001-X
ud Din F, Aman W, Ullah I, Qureshi OS, Mustapha O, Shafique S, Zeb A (2017) Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors. Int J Nanomedicine 12:7291. https://doi.org/10.2147/IJN.S146315
Vivek R, Thangam R, NipunBabu V, Rejeeth C, Sivasubramanian S, Gunasekaran P, Muthuchelian K, Kannan S (2014) Multifunctional HER2-antibody conjugated polymeric nanocarrier-based drug delivery system for multi-drug-resistant Breast cancer therapy. ACS Appl Mater Interfaces 6:6469–6480. https://doi.org/10.1021/am406012g
Wallat JD, Harrison JK, Pokorski JK (2018) pH responsive doxorubicin delivery by fluorous polymers for cancer treatment. Mol Pharm 15:2954–2962. https://doi.org/10.1021/acs.molpharmaceut.7b01046
Wang S, Kim G, Lee Y-EK, Hah HJ, Ethirajan M, Pandey RK, Kopelman R (2012) Multifunctional biodegradable polyacrylamide nanocarriers for cancer theranostics—A “see and treat” strategy. ACS Nano 6:6843–6851. https://doi.org/10.1021/nn301633m
Wang Y, Luo Z, Wang Z, You M, Xie S, Peng Y, Yang H (2018) Effect of curcumin-loaded nanoparticles on mitochondrial dysfunctions of Breast cancer cells. J Nanopart Res 20:283. https://doi.org/10.1007/s11051-018-4382-4
Wang Y, Yang M, Qian J, Xu W, Wang J, Hou G, Ji L, Suo A (2019) Sequentially self-assembled polysaccharide-based nanocomplexes for combined chemotherapy and photodynamic therapy of Breast cancer. Carbohydr Polym 203:203–213. https://doi.org/10.1016/j.carbpol.2018.09.035
Wei X, Liu L, Li X, Wang Y, Guo X, Zhao J, Zhou S (2019) Selectively targeting tumor-associated macrophages and tumor cells with polymeric micelles for enhanced cancer chemo-immunotherapy. J Control Release 313:42–53. https://doi.org/10.1016/j.jconrel.2019.09.021
Wong SK, Zainol I, Ng MP, Ng CH, Ooi H (2020) Dendrimer-like AB 2-type star polymers as nanocarriers for doxorubicin delivery to Breast cancer cells: synthesis, characterization, in-vitro release and cytotoxicity studies. J Polym Res 27:1–19. https://doi.org/10.1007/s10965-020-02089-2
Wu Y, Zhang X, Li H, Deng P, Li H, He T, Rong J, Zhao J, Liu Z (2018) A core/shell stabilized polysaccharide-based nanoparticle with intracellular environment-sensitive drug delivery for Breast cancer therapy. J Mater Chem B 6:6646–6659. https://doi.org/10.1039/C8TB00633D
Xu J, Sun J, Ho PY, Luo Z, Ma W, Zhao W, Rathod SB, Fernandez CA, Venkataramanan R, Xie W (2019) Creatine based polymer for codelivery of bioengineered MicroRNA and chemodrugs against Breast cancer lung metastasis. Biomaterials 210:25–40. https://doi.org/10.1016/j.biomaterials.2019.04.025
Xu L, Cheng L, Wang C, Peng R, Liu Z (2014) Conjugated polymers for photothermal therapy of cancer. Polym Chem 5:1573–1580. https://doi.org/10.1039/C3PY01196H
Xu X, Li L, Li X, Tao D, Zhang P, Gong J (2020b) Aptamer-protamine-siRNA nanoparticles in targeted therapy of ErbB3 positive Breast cancer cells. Int J Pharm:119963. https://doi.org/10.1016/j.ijpharm.2020.119963
Xu Y, Liu D, Hu J, Ding P, Chen M (2020a) Hyaluronic acid-coated pH sensitive poly (β-amino ester) nanoparticles for co-delivery of embelin and TRAIL plasmid for triple negative Breast cancer treatment. Int J Pharm 573:118637. https://doi.org/10.1016/j.ijpharm.2019.118637
Zhang L, Mu C, Zhang T, Wang Y, Wang Y, Fan L, Liu C, Chen H, Shen J, Wei K (2020) Systemic delivery of aptamer-conjugated xbp1 sirna nanoparticles for efficient suppression of her2+ Breast cancer. ACS Appl Mater Interfaces 12:32360–32371. https://doi.org/10.1021/acsami.0c07353
Zhao Y, Houston ZH, Simpson JD, Chen L, Fletcher NL, Fuchs AV, Blakey I, Thurecht KJ (2017) Using peptide aptamer targeted polymers as a model nanomedicine for investigating drug distribution in cancer nanotheranostics. Mol Pharm 14:3539–3549. https://doi.org/10.1021/acs.molpharmaceut.7b00560
Zhou M-r, Xie P-f, Gong J, Wu Y-F, Pei L, Chen J, Xu F (2020) Mechanistic investigation of cellular internalization routes of polymeric particles on Breast cancer cells: relevance for drug delivery applications. Appl Nanosci. https://doi.org/10.1007/s13204-020-01376-0
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The authors are thankful to DST-SERB for Research Funding (ECR/2017/000905) and H. R. Patel Institute of Pharmaceutical Education and Research, for providing necessary facilities.
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Tade, R.S. et al. (2022). Polymer-Based Nanoplatforms for Targeting Breast Cancer. In: Padhi, S., Behera, A., Lichtfouse, E. (eds) Polymeric nanoparticles for the treatment of solid tumors. Environmental Chemistry for a Sustainable World, vol 71. Springer, Cham. https://doi.org/10.1007/978-3-031-14848-4_14
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