NFL Odds Week 4: Lines, Spreads, Betting Trends For Every Game

Patrick Everson Sports Betting Expert

28 minute read

NFL Odds Week 4

NFL odds for Week 4 include a hugely juicy contest that's a rematch from last season's playoffs – and perhaps a preview of this season's playoffs. Tua Tagovailoa and his insanely high-scoring Miami Dolphins travel to face Josh Allen and the Buffalo Bills.

Here’s everything you need to know about the NFL odds Week 4 market: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on NFL Week 4 odds and action. Check back regularly for updates.

NFL Odds for Every Game of NFL Week 4

Seattle Seahawks vs New York Giants Odds

• Opening point spread: Seahawks -1.5
• Opening moneyline: Giants -120/Seahawks even
• Opening total: Over/Under 45 points scored
• Time: 8:15 p.m. ET Monday (ABC)

UPDATE 5:30 P.M. ET MONDAY: Less than three hours before kickoff, the Seahawks are 2.5-point favorites at PointsBet, a Fanatics Experience. On Sept. 24, this matchup opened Seattle -1 and quickly jumped the fence to New York -1/-1.5.

After spending a couple days at pick, the Seahawks went to -1 Thursday, -1.5 Saturday and -2.5 today. But while 77% of spread tickets are on Seattle, short 'dog New York is getting 56% of spread money.

PointsBet's total opened at 45 and peaked at 47.5 multiple times over the past week, including today. It's now at 46.5 with two way play, as tickets are dead even and 58% of money is on the Under.

Seahawks running back Kenneth Walker scoring an anytime touchdown has the most tickets and money of any player prop tonight at PointsBet. And Seahawks wideout DK Metcalf has seen his receiving yards prop stretch from 60.5 to 70.5 yards, with 93.5% of bets and practically every dollar on the Over.

UPDATE 1 P.M. ET FRIDAY: This line jumped the fence early at BetMGM, from Seattle -1.5 to New York -1 at lunchtime Monday. The Giants have spent time at -1.5 this week and are currently back at -1.

Seattle is taking 75% of early spread bets, while 54% of early spread money is on New York.

The total opened at 45 and stretched to 47.5 by Wednesday evening, with no movement since. That said, the Under is seeing 62% of tickets/58% of money.

UPDATE 10 P.M. ET SUNDAY: New York has already played in two prime-time games, getting drubbed in both meetings. The Giants (1-2 SU/0-3 ATS) get another shot in the Monday nighter on the NFL Week 4 odds board.

In Week 3, New York – minus running back Saquon Barkley, among others – was a 10.5-point 'dog at San Francisco. The Giants lost 30-12 in the Thursday night game. So on the bright side, the G-Men have extra days to rest up and perhaps get Barkley back in the mix.

Meanwhile, Seattle (2-1 SU and ATS) pulled away from Carolina in the fourth quarter, winning 37-27 as 4.5-point home chalk.

"The Seahawks struggled today before eventually covering against Carolina," Michaelson said. "Without Barkley, the Giants' offense looks like it will struggle. And for a third prime-time game in four weeks, we will likely need the Giants as a 'dog. Maybe they'll come through for us this time."

In-Progress Games for NFL Week 4

No games in progress at the moment.

Completed Games for NFL Week 4

Kansas City Chiefs vs New York Jets Odds

• Opening point spread: Chiefs -8
• Opening moneyline: Chiefs -500/Jets +375
• Opening total: Over/Under 44 points scored
• Time: 8:20 p.m. ET Sunday (NBC)

UPDATE 6:20 P.M. ET SUNDAY: Two hours before kickoff, Kansas City is down to -7.5 at TwinSpires Sportsbook, right where this matchup opened last Sunday. In the interim, the Chiefs went to -8 and -8.5, with the move to -7.5 coming today.

"Sharp play on the Jets +8.5," TwinSpires director of retail sports Zachary Lucas said, before noting the Chiefs are a huge public play, with liability in every direction. "Our day comes down to K.C. Massive public support for the Chiefs – teasers, parlays, everything is on K.C."

On straight spread bets, the Chiefs are hauling in 90% of tickets/86% of money.

The total is down to 41.5 from a 44 opener, with 55% of tickets/66% of dollars on the Under.

UPDATE 1 P.M. ET FRIDAY: BetMGM bumped K.C. from -9 to -9.5 Monday, then fell back to -8.5 Thursday. But that decline isn't showing up in the action, which is thoroughly one-sided heading to the weekend. Kansas City is attracting 93% of spread tickets/95% of spread cash.

In fact, at BetMGM, the Chiefs have taken the most spread tickets and most spread money of any team on the NFL Week 4 odds board.

The total opened at 42.5, fell to 42 Wednesday and briefly got as low as 40.5 Thursday. It's now at 41.5, with ticket count 2/1 and money almost 3/1 on the Over.

UPDATE 10 P.M. ET SUNDAY: After looking sluggish the first two weeks, Patrick Mahomes and the Chiefs found their form in Week 3. The Chicago Bears can help do that. Kansas City (2-1 SU and ATS) led 34-0 at halftime on its way to a 41-10 victory giving 12.5 points at home.

New York got a surprising Week 1 home win over Buffalo, a troops-rallying effort after Aaron Rodgers got hurt. But Zach Wilson and the Jets haven't done much since. In Week 3, Gang Green lost to New England 15-10 catching 2.5 points at home.

The Chiefs-Jets line advanced from K.C. -8 to -9 within a minute of going up this evening. Conversely, the total dipped a point to 43.

"The public will bet K.C., and everything parlay/teaser/moneyline parlay will be tied to the Chiefs as the standalone game on Sunday night," Michaelson said. "This could get higher if Mahomes is confirmed in, after he got banged up against Chicago. But the Chiefs certainly looked good today.

"Zach Wilson's Jets are a different proposition than Aaron Rodgers' Jets, and this will likely be our biggest decision of the week."

Mahomes tweaked his right ankle against Chicago, but the issue doesn't appear serious.

Las Vegas Raiders vs Los Angeles Chargers Odds

• Opening point spread: Chargers -4
• Opening moneyline: Chargers -220/Raiders +180
• Opening total: Over/Under 49.5 points scored
• Time: 4:05 p.m. ET Sunday (CBS)

UPDATE 2:30 P.M. ET SUNDAY: TwinSpires Sportsbook opened the Chargers -6 and sits at L.A. -6.5 with 90 minutes until kickoff. Spread tickets are running 2/1 and spread money 3/1 on Los Angeles, facing a Las Vegas squad without starting QB Jimmy Garoppolo (concussion).

"It's a mix of sharp and public play on the Chargers. Las Vegas will be needed," TwinSpires director of retail sports Zachary Lucas said.

The total is up a tick from 47.5 to 48, with tickets 2/1 and money 2.5/1 on the Over.

UPDATE 1 P.M. ET FRIDAY: The Chargers advanced from -4.5 to -5.5 Monday at BetMGM, and they've been at -5.5 (-105) since Thursday afternoon. Tickets and money are in the 3/1 range on Los Angeles.

BetMGM's total opened at 50.5, bottomed out at 47.5 Monday afternoon and went to 48.5 Wednesday afternoon. The Over is netting 59% of early tickets, while 60% of early money is on the Under.

UPDATE 10 P.M. ET SUNDAY: Los Angeles finally found its way into the win column in Week 3. The Chargers (1-2 SU and ATS) held off Minnesota 28-24 as 1-point road 'dogs.

Las Vegas (1-2 SU and ATS) was a sharp darling much of the past week, opening +1.5 and closing -3 vs. Pittsburgh. But the Raiders fell 23-18 in their home opener.

Said Michaelson prior to Sunday night's Steelers-Raiders tilt:

"Things will change after the Raiders play. But the Chargers looked basically like the same team that lost the first two games – except the breaks went their way this time. We took a bet to move us up on the total. The Chargers attract lots of Over bets."

That sharp bet helped lift the total to 50.5 in The SuperBook's NFL odds Week 4 market.

New England Patriots vs Dallas Cowboys Odds

• Opening point spread: Cowboys -7
• Opening moneyline: Cowboys -300/Patriots +240
• Opening total: Over/Under 42 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

UPDATE 2:30 P.M. ET SUNDAY: About two hours before kickoff, the Cowboys are down to -6 at TwinSpires, after opening -7 and spending time at -6.5. Dallas is getting 58% of spread bets, while 56% of spread money is on New England.

"A Belichick-led team getting 7? That was snapped up quickly by our bettors. We'll need Dallas in this one," Lucas said.

The total rose from 42.5 to 43.5 and is now 43, with 60% of tickets/62% of money on the Over.

UPDATE 1 P.M. ET FRIDAY: BetMGM moved the Cowboys from -7 flat to -7 (-105) Monday, then went to -6.5 (-115) Wednesday night. The visiting 'dog Patriots are drawing 55% of spread bets/65% of spread dollars.

BetMGM's total initially inched down from 42 to 41.5 Sunday night. The number went to 42.5 Monday, 43 Tuesday and 43.5 Thursday. However, early tickets are 4/1 and early money 3/1 on the Under.

UPDATE 10 P.M. ET SUNDAY: Dallas looked like one of the league's best teams through two weeks. But a huge slice of humble pie was served in Week 3. The Cowboys (2-1 SU and ATS) were 11.5-point favorites at Arizona and never led in a 28-16 loss.

New England had to face two top-tier teams in Weeks 1 and 2, losing at home to Philadelphia and Miami. The Patriots (1-2 SU and ATS) got right in a Week 3 rock fight against the New York Jets. New England notched a 15-10 road victory laying 2.5 points.

The Pats-Cowboys spread is stable tonight, but the total inched down to 41.5 at The SuperBook.

Arizona Cardinals vs San Francisco 49ers Odds

• Opening point spread: 49ers -14.5
• Opening moneyline: 49ers -1000/Cardinals +600
• Opening total: Over/Under 42 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

UPDATE 2:30 P.M. ET SUNDAY: San Francisco has been pinned to -14 all week at TwinSpires Sportsbook. Arizona, which is 3-0 ATS, is getting 58% of spread bets/57% of spread money.

"Bettors are buying into the Arizona hype and taking the two TDs, expecting the Cardinals to get to 4-0 ATS," Lucas said.

The total opened at 42.5, peaked at 44 and is now 43.5. The Over is drawing 59% of bets/67% of money.

"Sharp play on Over 42.5," Lucas said.

UPDATE 9 P.M. ET WEDNESDAY: Some bettors are starting to take note of Arizona, which was thought to be tanking before the season even began. The Cards are one of just three teams with a perfect 3-0 ATS mark.

TwinSpires Sportsbook opened the Niners -14 and is still there. The Cardinals are attracting 58% of spread tickets/56% of spread money in the early going.

"Bettors are buying into the Arizona hype. Getting 14 points in a divisional matchup is enticing bettors," Lucas said.

TwinSpires' total climbed from 42.5 to 44, with 57% of tickets/73% of dollars on the Over.

UPDATE 10 P.M. ET SUNDAY: After a 3-0 SU start, San Francisco is atop the Super Bowl odds board. In the Week 3 Thursday nighter, the Niners (2-1 ATS) rolled over the beat-up New York Giants 30-12 as 10.5-point home favorites.

Arizona pulled the biggest upset of the season thus far. Catching 11.5 points, the Cardinals (1-2 SU/3-0 ATS) shocked Dallas 28-16.

The Cards-Niners line backed up to -14 about an hour after opening this evening at The SuperBook.

Miami Dolphins vs Buffalo Bills Odds

• Opening point spread: Bills -2.5
• Opening moneyline: Bills -145/Dolphins +125
• Opening total: Over/Under 53 points scored
• Time: 1 p.m. ET Sunday (CBS)

UPDATE 10:15 A.M. ET SUNDAY: Less than three hours before kickoff, Buffalo is at -2.5 (-120) in BetMGM's NFL odds Week 4 market. The Bills opened -2.5 flat, went to -3 Tuesday, then receded to -2.5 (-120) Wednesday.

It's two-way spread play, with 56% of tickets on Miami/56% of spread cash on Buffalo.

"The two most-bet games this week are Bills-Dolphins and Chiefs-Jets. In the early game, the best outcome for the sportsbook would be for the Bills to win but not cover," BetMGM trader Seamus Magee said.

BetMGM's total opened at 53.5, peaked at 54.5 Wednesday and returned to 53.5 Thursday. Tickets and money are in the 3/1 range on the Over.

UPDATE 9 P.M. ET WEDNESDAY: Buffalo opened -2.5 at TwinSpires and is up to -3, but it's two-way play. The Dolphins are getting 59% of early bets, while 58% of early cash is on the Bills.

"It's looking like a Pros vs. Joes matchup. The public isn't passing up the 3-0 Dolphins getting points, with the way their offense has looked," Lucas said.

The total initially nudged down from 54 to 53.5, but it's now back at 54. The Over is seeing 70% of tickets/54% of money in the early going.

"Sharp play on Under 54," Lucas said.

UPDATE 10 P.M. ET SUNDAY: This is easily the best game on the NFL Week 4 odds board, with both teams coming off blowout wins.

Miami was absolutely spectacular in beating the daylights out of Denver. The Dolphins (3-0 SU and ATS) scored 35 points in each half of a 70-20 victory giving 6 points at home.

Buffalo wasn't quite that overwhelming, but took care of business nonetheless. The Bills (2-1 SU and ATS) dumped Washington 37-3 as 5.5-point road faves.

"Both teams were impressive today, but making the Dolphins a field-goal underdog after the offensive explosion today felt unwise," Michaelson said. "I could see the public betting the Dolphins as a 'dog."

The total is already up a half-point tonight to 53.5 at The SuperBook.

In last season's Wild Card round, without Tua Tagovailoa, Miami gave the host Bills all they could handle. Buffalo ultimately prevailed 34-31 laying 14 points.

Washington Commanders vs Philadelphia Eagles Odds

• Opening point spread: Eagles -7
• Opening moneyline: Eagles -310/Commanders +250
• Opening total: Over/Under 44.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

UPDATE 10:15 A.M. SUNDAY: Philly went from -7 to -8.5 by Tuesday at BetMGM, then briefly touched -9.5 Saturday. The Eagles are now at -8.5 (-115), with tickets and money running 3/1 on Philadelphia.

The total initially rose from 44.5 to 45.5 Tuesday. But it dropped to 43.5 by Wednesday and went to 43 this morning. Ticket count is almost even, while 60% of money is on the Under at BetMGM.

UPDATE 9 P.M. ET WEDNESDAY: TwinSpires opened later than others on this game, making Philadelphia an 8.5-point favorite. That's been bet down to Eagles -8, with 67% of early tickets/53% of early money on Philly.

"Another week where we're seeing sharp play on an Eagles opponent," Lucas said.

Philadelphia (3-0 SU/2-1 ATS) is coming off a 25-11 Monday night victory laying 6 points at Tampa Bay.

The total is on the move downward, from 45 to 43.5. The Under is drawing 58% of tickets/62% of money at TwinSpires.

UPDATE 10 P.M. ET SUNDAY: Washington (2-1 SU/1-2 ATS) gave up the first 37 points against Buffalo in a 37-3 loss as a 5.5-point home pup.

Defending NFC champion Philadelphia (2-0 SU/1-1 ATS) still has Week 3 work to do. The Eagles travel to face Tampa Bay on Monday night.

"We'll see how we stand after the Eagles play Monday night. But the public will almost certainly bet the Eagles at home laying just a touchdown," Michaelson said. "Going above a TD we think would be inviting the wiseguys on Washington. We will need the Commanders."

Baltimore Ravens vs Cleveland Browns Odds

• Opening point spread: Pick
• Opening moneyline: Browns -140/Ravens +120
• Opening total: Over/Under 43.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

UPDATE 10:30 A.M. ET SUNDAY: Cleveland rebounded from -1 to -2.5 over the weekend at BetMGM, even though QB Deshaun Watson is a game-time decision. Then moments ago, the Browns dipped to -1.5.

Spread ticket count is dead even, while 54% of spread money is on Baltimore.

The total tumbled from 42.5 to 38.5, where it sits now. Ticket count is 2/1 on the Under, but money is nearly even.

UPDATE 12:30 P.M. ET FRIDAY: BetMGM opened the Browns -2.5 in the NFL odds Week 4 market, and the line went to -3 Wednesday. But the number fell back this afternoon, making stops at Cleveland -2.5/-1.5 on the way to the current -1.

That's due largely to Browns QB Deshaun Watson (shoulder) being listed as questionable. Baltimore is seeing 53% of early spread tickets/58% of early spread cash.

BetMGM's total was already down to 40.5 Wednesday, from a 42.5 opener. In the past 30 minutes or so, it dipped to 39 (Over -120), then inched up to 39.5. Ticket count is 5/1 and money 9/1 on the Under in the early going.

UPDATE 10 P.M. ET SUNDAY: Cleveland fared just fine in its first game without Nick Chubb, who suffered a knee injury in Week 2. The Browns (2-1 SU and ATS) were 3.5-point home favorites against Tennessee and rolled 27-3.

Meanwhile, Baltimore (2-1 SU and ATS) suffered one of the more surprising losses of Week 3. The Ravens, laying 7.5 points at home, tumbled to Indianapolis 22-19 in overtime.

The Ravens-Browns line has already bounced around tonight. After opening pick 'em, it initially went to Ravens -1. But it quickly returned to pick 'em, en route to hopping the fence to Browns -1, then Browns -2.

The total also moved early, from 43 to 42.5.

Tampa Bay Buccaneers vs New Orleans Saints Odds

• Opening point spread: Saints -3
• Opening moneyline: Saints -155/Buccaneers +135
• Opening total: Over/Under 40.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

UPDATE 10:30 A.M. ET SUNDAY: New Orleans remains -3.5 at BetMGM (see below update), though with a modest juice adjustment from -105 to the flat -110. Ticket count is almost 3/1 and money 2/1 on the Saints.

The total returned to the 40.5 opener this morning, with tickets literally dead even and 60% of money on the Over.

UPDATE 12:30 P.M. ET FRIDAY: The Saints spent the first couple days of the week at various iterations of -3, then went to -3.5 (-105) Wednesday at BetMGM. The line hasn't moved since. However, ticket count is 4/1 and money 2/1 on the underdog Buccaneers.

BetMGM's total opened at 40.5 and is now 39.5, with 61% of tickets on the Under, but 84% of cash on the Over.

UPDATE 10 P.M. ET SUNDAY: New Orleans (2-1 SU/0-2-1 ATS) blew a 17-0 fourth-quarter lead while getting the first blemish on its SU record. The Saints lost 18-17 as 1.5-point favorites at Green Bay.

Tampa Bay (2-0 SU and ATS) still has a tough Week 3 challenge Monday night against visiting Philadelphia.

The Bucs-Saints spread got a modest juice adjustment tonight, from Saints -3 flat to -3 (even).

Cincinnati Bengals vs Tennessee Titans Odds

• Opening point spread: Titans -2.5
• Opening moneyline: Titans -110/Bengals -110
• Opening total: Over/Under 42 points scored
• Time: 1 p.m. ET Sunday (FOX)

UPDATE 10:30 A.M. ET SUNDAY: This line jumped the fence early in the week at BetMGM, once it became apparent Joe Burrow would start today for Cincy. The Titans opened -1.5, and the number went to Bengals -2.5 late Monday night.

Cincinnati is currently -2.5 (-115), with ticket count almost 4/1 and money 2.5/1-plus on the Bengals.

The total opened at 42.5, bottomed out at 40.5 Thursday and is now 41.5. The Under is getting 54% of tickets/65% of money at BetMGM.

UPDATE 9 P.M. ET WEDNESDAY: Cincinnati (1-2 SU/0-2-1 ATS) saw Joe Burrow shake off a calf injury to play in Week 3. The Bengals posted a 19-16 win to push as 3-point home faves against the Rams.

TwinSpires pegged Cincy 2.5-point road chalk for Week 4 and hasn't moved off that number. Ticket count is 2.5/1 and money 2/1 on the Bengals.

"The public is starting to believe in the Bengals again. Short road chalk is always popular," Lucas said.

UPDATE 10 P.M. ET SUNDAY: Tennessee (1-2 SU/2-1 ATS) was a trendy 'dog in Week 3, but failed to deliver. The Titans tumbled to the Browns 27-3 getting 3.5 points on the road.

Cincinnati (0-2 SU and ATS) hopes to get its first win when it hosts the Los Angeles Rams in a Week 2 Monday night game. Bengals QB Joe Burrow's status for that game is uncertain, and therefore it's uncertain if he'll play against the Titans, either.

But The SuperBook went ahead and posted Bengals-Titans in its NFL odds Week 4 market.

"Obviously, this spread is completely dependent on Joe Burrow's health," Michaelson said. "We opened on the high end, anticipating that Burrow does not play. It could close Titans higher or Cincinnati could close the favorite. He's a pretty important player."

The line and total are both stable tonight.

Minnesota Vikings vs Carolina Panthers Odds

• Opening point spread: Vikings -3
• Opening moneyline: Vikings -180/Panthers +150
• Opening total: Over/Under 44.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

UPDATE 12:30 P.M. ET SUNDAY: Thirty minutes pre-kick, the Vikings are 4-point favorites at Fanatics Sportsbook. Minnesota opened -3 (-105) and got as high as -4.5 a couple times, including this morning.

It's all Vikings on the spread, at 84% of tickets/87% of money. And moneyline are similarly lopsided toward Minnesota.

Fanatics' total opened at 44.5, topped out at 46.5 Thursday and nudged down to 46 in the past hour. The Over is taking 60% of tickets/79% of money.

UPDATE 12:30 P.M. ET FRIDAY: The Vikings have steadily climbed throughout the week at BetMGM. Minnesota opened -3, went to -3.5 Monday, -4 Wednesday and -4.5 (-105) Thursday.

The Vikes are now -4.5 flat, with early ticket count 4/1 and early money almost 8/1.

BetMGM's total went from 44.5 to 45.5 Monday, then to 46.5 Thursday. Tickets are almost 3/1 and money 9/1 on the Over.

UPDATE 10 P.M. ET SUNDAY: Minnesota (0-3 SU/0-2-1 ATS) still hasn't notched a win against opponents nor oddsmakers. In Week 3, the Vikings were in a back-and-forth battle with the Chargers and came up short 28-24 as 1-point home faves.

Carolina, with Andy Dalton subbing for injured rookie QB Bryce Young, stuck with Seattle well into the fourth quarter. But the Panthers (0-3 SU/1-2 ATS) ultimately fell 37-27 getting 4.5 points.

There's been no early movement on the line or total in The SuperBook's NFL odds Week 4 market.

Denver Broncos vs Chicago Bears Odds

• Opening point spread: Broncos -2.5 (-120)
• Opening moneyline: Broncos -170/Bears +145
• Opening total: Over/Under 45 points scored
• Time: 1 p.m. ET Sunday (CBS)

UPDATE 12:30 P.M. ET SUNDAY: Denver opened -2.5 at Fanatics, quickly got to -3.5 and spent most of the week there. This morning, though, the Broncos moved down to -3 (-105).

Still, tickets are beyond 2.5/1 and money almost 9/1 on the Broncos.

The total opened at 44.5, slowly climbed to 47 by Saturday, then toggled between 47 and 46.5. It's now 47, with tickets 3/1 on the Under and money running almost even.

UPDATE 9 P.M. ET WEDNESDAY: Somehow, even after last week's dreadful performance at Miami, Denver has moved from -2.5 to -3 and on to -3.5 at TwinSpires. The Broncos are netting 60% of spread tickets/77% of spread money midweek.

"It's a mix of sharp and public play on the Broncos," Lucas said. "Despite how bad Denver has looked, they're still seeing money. It shows you how poorly perceived Chicago is. It's ugly, but we'll need Chicago."

The total moved from 45.5 to 46, with 65% of bets/61% of cash on the Over.

UPDATE 10 P.M. ET SUNDAY: Based on what we saw in Week 3, these two teams might be the worst in the NFL.

Denver (0-3 SU and ATS) is off to an extremely poor start under new coach Sean Payton. The Broncos went to Miami as 6-point 'dogs and got absolutely manhandled 70-20.

Meanwhile, Chicago (0-3 SU and ATS) trailed 34-0 at halftime against Kansas City and lost 41-10 as 12.5-point road pups.

The Broncos-Bears line has seen some movement tonight at The SuperBook. Denver moved from -2.5 (-120) to -3 flat, then to -3 (-120). The total is also on the move early, from 45 to 45.5 to 46. Go figure, for two teams that were outscored by a combined 111-30 in Week 3.

Los Angeles Rams vs Indianapolis Colts

• Opening point spread: Pick
• Opening moneyline: Rams -110/Colts -110
• Opening total: Over/Under 45 points scored
• Time: 1 p.m. ET Sunday (FOX)

UPDATE 12:30 P.M. ET SUNDAY: After the Colts spent all week as a short favorite at BetMGM, the line flipped this morning to Rams -1. Los Angeles is seeing 61% of spread tickets/62% of spread dollars.

The total opened at 45, topped out at 46.5 Tuesday, then made its way down to 44.5 by late this morning. Still, tickets and money are in the 4/1 range on the Over.

UPDATE 12:30 P.M. ET FRIDAY: Indy has been the shortest of favorites all week at BetMGM. After opening -1, the Colts crept to -1.5 late Monday night, then returned to -1 Tuesday morning. The line has been at Indianapolis -1 (-105) since Wednesday evening.

Short 'dog Los Angeles is drawing 58% of early spread bets/67% of early spread dollars.

The total dipped from 45 to 44.5 Tuesday, but rebounded within a few hours to 46.5. It's been at 45.5 since Thursday morning, with tickets running 4/1 and money almost 6/1 on the Over.

UPDATE 10 P.M. ET SUNDAY: Indianapolis notched a notable upset in Week 3, helping kill a bundle of moneyline parlays/teasers for public/recreational bettors. The Colts closed as 7.5-point pups at Baltimore and won 22-19 on a field goal with 1:09 left in overtime.

Los Angeles still has Week 3 work to do. The Rams (1-1 SU/2-0 ATS) travel to Cincinnati for a Monday night tilt.

Pittsburgh Steelers vs Houston Texans Odds

• Opening point spread: Steelers -3
• Opening moneyline: Steelers -165/Texans +142
• Opening total: Over/Under 40.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

UPDATE 12:30 P.M. ET SUNDAY: Pittsburgh opened -4 at Fanatics Sportsbook and dropped to -2 by Thursday, with stops along the way. The Steelers climbed back to -3 (-105) Saturday and are now -3 (-105). Ticket count is 3/1 and money almost 4/1 on Pittsburgh.

The total opened at 40.5, peaked at 42.5 multiple times Friday/Saturday, but is now down to 41. It's almost perfect two-way play on the total.

UPDATE 1 P.M. ET FRIDAY: BetMGM pegged the Steelers -3.5 (-105) to open and spent the rest of the week at various iterations of -3. Pittsburgh is currently -3 (-105), while underdog Houston is taking 51% of tickets/56% of cash.

The total opened at 40.5 and peaked at 42.5 briefly Wednesday before settling at 42. Ticket count is 2/1 and money 5/1-plus on the Over.

UPDATE 10 P.M. ET SUNDAY: Much like Indy, Houston pulled off a road upset that killed countless parlays/moneyline parlays and teasers. The Texans (1-2 SU and ATS) closed as 7.5-point underdogs and stunned Jacksonville 37-17.

Pittsburgh (2-1 SU and ATS) held off Las Vegas 23-18 getting 3 points on the road.

Atlanta Falcons vs Jacksonville Jaguars Odds

• Opening point spread: Jaguars -3 (even)
• Opening moneyline: Jaguars -155/Falcons +135
• Opening total: Over/Under 43.5 points scored
• Time: 9:30 a.m. ET Sunday (ESPN+)

UPDATE 12:30 P.M. ET FRIDAY: Jacksonville has been painted to -3 pretty much all week at BetMGM. Spread tickets are running 3/1 and spread money 5/1 on the Jags for this contest in London.

The total was at 43.5 all week until dipping to 43 this morning. Tickets and money are in the 2.5/1 range on the Under.

UPDATE 10 P.M. ET SUNDAY: Both teams are coming off Week 3 losses as they make the long journey to London for a neutral-site game.

Jacksonville's loss was far more a surprise. The Jags (1-2 SU and ATS), laying 7.5 points at home, got trucked by Houston 37-17.

Atlanta (2-1 SU/1-2 ATS) went to Detroit as a 3.5-point 'dog and mustered just two field goals in a 20-6 setback.

The SuperBook only adjusted the juice tonight in its NFL odds Week 4 market, moving from Jags -3 (even) to Jags -3 flat.

Detroit Lions vs Green Bay Packers Odds

• Opening point spread: Lions -2
• Opening moneyline: Lions -125/Packers +105
• Opening total: Over/Under 44.5 points scored
• Time: 8:15 p.m. ET Thursday (Prime)

UPDATE 7:30 P.M. ET THURSDAY: With kickoff looming, Detroit is laying 2.5 points in the NFL odds Week 4 market at PointsBet, a Fanatics Experience. The Lions opened -2 Sunday night and got as low as -1 a few times during the week before advancing to -2.5 this afternoon.

Point-spread ticket count is 4/1 and spread money 5/1 on the road favorite Lions.

The total opened at 44.5, peaked at 46.5 early Wednesday, then dialed down to 44.5 again a couple times today. It's now 45.5 on almost dead-even two-way action at PointsBet.

UPDATE 9 P.M. ET WEDNESDAY: This number has toggled around in TwinSpires Sportsbook's NFL odds Week 4 market. Last week's lookahead line was Packers -1.5, but when the game opened Sunday night, it was Lions -2.

Earlier today, the number was Lions -1, and TwinSpires is now splitting the difference at Detroit -1.5. Green Bay is taking 63% of early tickets/59% of early money.

"Green Bay as a slight home 'dog vs. the Lions is hard to pass up. We'll need the Lions on Thursday Night Football," TwinSpires director of retail sports Zachary Lucas said.

TwinSpires' total is up a point to 46, with 60% of tickets/55% of money on the Over.

UPDATE 10 P.M. ET SUNDAY: Detroit (2-1 SU and ATS) bounced back from its Week 2 home loss against Seattle. The Lions went off as 3.5-point home favorites and beat Atlanta 20-6.

Green Bay (2-1 SU/3-0 ATS) rallied from a 17-0 fourth-quarter deficit to top New Orleans. The Packers squeaked out an 18-17 victory to cash as 1.5-point home underdogs.

The SuperBook hasn't moved off Detroit -2 tonight.

"We closed at pick in [last week's] lookahead, but re-opened Lions -2 and with a lower total, after Detroit's defense looked much better today," SuperBook risk supervisor Chase Michaelson said tonight. "Green Bay's comeback win was less impressive. It's hard to know what we'll need here, because the public isn't sure about Jordan Love yet."

Where to place a bet this NFL Season?

• Use our exclusive BetMGM Bonus Code VIBONUS1500 to unlock BetMGM’s welcome offer for new sportsbook users!
• Compare the latest NFL Odds from the best sportsbooks before placing a bet on this week's games.
• Check out the North Carolina Sportsbooks just before they launch legal online sports betting.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson