Purines and Pyrimidines Quiz

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The following enzymes are involved in the catabolism of AMP to uric acid. The correct order of their use is:

1. A deaminase

2. A nucleoside phosphorylase

3. Xanthine oxidase

20 points

1, 2, 3

1, 3, 2,

1, 4, 2,

3, 2, 1, 4

3, 1, 2,

What are the nucleotide components of nucleic acids? *

15 points

Nitrogen base and sugar

Nitrogen base, sugar, and PO4

Nitrogen base, sugar, and SO4

Nitrogen base, PO4 and salt

Nitrogen base, salt, and sugar

In the catabolism of CTP: *

20 points

Uric acid is an end product

Nitrogen will be released in the form of ammonia

The nitrogen-containing ring will be oxidixed

The final product will have the same type of nitrogen-containign rings a CTP

Hpoxanthine will be an intermediate

Involve(s) reduction and cleavage of the nitrogen-containing ring

A. Catabolism of guanine

B. Catabolism of uracil

15 points

A only

B only

Both A and B

Neither A or B

Other:

The conversion of xanthine into uric acid is catalyzed by *

15 points

Xanthine oxidase

Formyltransferase

Adenylsiccinase

or Adenosine deaminase

Lipase

Which of the following would NOT be expected to contribute to hyperuricemia (gout)? *

15 points

Unusually high levels of PRPP

Inhibition of xanthine oxidase

Unusually high turnover of nucleic acids

High activity of adenosine deaminase

Deficiency of HG-PRT

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